Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes
Cardiac parasympathetic dysfunction in T2DM rats is due, in part, to functional remodeling of CVP neurons. As leptin resistance develops as early as 4 weeks post-T2DM induction, diminished leptin receptors-UCP2 signaling may contribute to CVP neuronal dysregulation.
Authors
- Huiyin Tu
- L. Whitney (ORCID: https://orcid.org/0000-0001-8977-9951)
- Yulong Li (ORCID: https://orcid.org/0000-0002-4219-9041)
- Anthony J. Evans
- Kassidy Carpenter
- Boris Shabaltiy
Institutions
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fphys.2025.1547901
- Citations
- 1
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Institutes of Health