Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains

Our results provide fundamental insight into the conserved molecular pathways altered by opioids across species, with evidence suggesting that alterations in females with OUD may be driven by drug exposure, while alterations in males with OUD may be driven by volitional intake.

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Publication Details

Journal
Biological Psychiatry Global Open Science
Published
2025-02-26
DOI
https://doi.org/10.1016/j.bpsgos.2025.100476
Citations
6
Primary Topic
Neurotransmitter Receptor Influence on Behavior
Type
article
Field-Weighted Citation Impact
4.55

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article

Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains

Leah C. Solberg Woods, Marianne L. Seney, Darrell Eacret, Navsharan Singh et al.
6 citations
Biological Psychiatry Global Open Science
Neurotransmitter Receptor Influence on Behavior
4.55
article

Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains

Leah C. Solberg Woods, Marianne L. Seney, Darrell Eacret, Navsharan Singh, Julie A. Blendy, George C. Tseng, Abraham A. Palmer, Benjamin R. Williams, Ryan W. Logan, Nicole L. Horan, Olivier George, Xiangning Xue, Joseph A. Seggio, Lisa Maturin, BaDoi N. Phan, Mackenzie C. Gamble, Julie M. Michaud, Madeline K. Fish, Micah A. Shelton
article en
6 citations

Abstract

Our results provide fundamental insight into the conserved molecular pathways altered by opioids across species, with evidence suggesting that alterations in females with OUD may be driven by drug exposure, while alterations in males with OUD may be driven by volitional intake.

Biological Psychiatry Global Open ScienceVol. 5(3)
Boston University (US), University of Massachusetts Chan Medical School (US), University of Pittsburgh (US), Bridgewater State University (US), University of California San Diego (US), Translational Therapeutics (United States) (US), Wake Forest University (US), University of Pennsylvania (US)
National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse
Good health and well-being
Openalex Percentile: Top 6%
Neurotransmitter Receptor Influence on Behavior
4.55
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