Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains
Our results provide fundamental insight into the conserved molecular pathways altered by opioids across species, with evidence suggesting that alterations in females with OUD may be driven by drug exposure, while alterations in males with OUD may be driven by volitional intake.
Authors
- Leah C. Solberg Woods (ORCID: https://orcid.org/0000-0002-7943-798X)
- Marianne L. Seney
- Darrell Eacret
- Navsharan Singh (ORCID: https://orcid.org/0000-0002-5501-0615)
- Julie A. Blendy (ORCID: https://orcid.org/0000-0003-1705-9001)
- George C. Tseng (ORCID: https://orcid.org/0000-0002-5447-1014)
- Abraham A. Palmer (ORCID: https://orcid.org/0000-0003-3634-0747)
- Benjamin R. Williams (ORCID: https://orcid.org/0000-0001-6167-818X)
- Ryan W. Logan (ORCID: https://orcid.org/0000-0001-8579-015X)
- Nicole L. Horan (ORCID: https://orcid.org/0000-0002-5369-0063)
- Olivier George (ORCID: https://orcid.org/0000-0002-3700-5003)
- Xiangning Xue (ORCID: https://orcid.org/0000-0002-5775-1193)
- Joseph A. Seggio (ORCID: https://orcid.org/0000-0002-7315-1462)
- Lisa Maturin
- BaDoi N. Phan (ORCID: https://orcid.org/0000-0001-6331-5980)
- Mackenzie C. Gamble (ORCID: https://orcid.org/0000-0003-2540-2631)
- Julie M. Michaud
- Madeline K. Fish (ORCID: https://orcid.org/0000-0002-7796-7477)
- Micah A. Shelton
Institutions
- Boston University (US)
- University of Massachusetts Chan Medical School (US)
- University of Pittsburgh (US)
- Bridgewater State University (US)
- University of California San Diego (US)
- Translational Therapeutics (United States) (US)
- Wake Forest University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100476
- Citations
- 6
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute on Drug Abuse