Xanthine Derivative <scp>KMUP</scp>‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis
Our study demonstrated that KMUP-3 attenuates Pg-LPS-enhanced osteoclastogenesis and macrophage pyroptosis. Notably, KMUP-3 alleviates alveolar bone loss in experimental periodontitis rats and thus suggests its certain role in safeguarding against periodontal bone resorption.
Authors
- Mengxuan Lin (ORCID: https://orcid.org/0000-0001-8947-5421)
- Jwu‐Lai Yeh (ORCID: https://orcid.org/0000-0001-7101-5865)
- Bin‐Nan Wu (ORCID: https://orcid.org/0000-0001-6593-5120)
- Kai‐Fang Hu (ORCID: https://orcid.org/0000-0001-8080-0339)
- Ching‐Jiunn Tseng (ORCID: https://orcid.org/0000-0002-5846-1817)
- Jong‐Hau Hsu (ORCID: https://orcid.org/0000-0002-2690-7247)
- Shang‐En Huang (ORCID: https://orcid.org/0000-0003-2324-9178)
- Zen‐Kong Dai (ORCID: https://orcid.org/0000-0003-3280-2545)
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1111/jre.13393
- Citations
- 2
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Kaohsiung Medical University
- National Science and Technology Council