Beyond Infection: A Case of Doxycycline-Induced Mania and Prolonged Neuropsychiatric Disturbance

Doxycycline is commonly used in respiratory medicine to treat bacterial lower respiratory tract infections and is also a frequent choice in dermatology for various skin conditions. However, neuropsychiatric adverse reactions to doxycycline are rarely documented in the literature. Even less frequently reported is the persistence of such reactions for up to six weeks after discontinuing a 100 mg doxycycline tablet. We present a rare case of doxycycline-induced mania and psychosis in a patient who had taken the antibiotic for only three days, yet experienced severe neuropsychiatric symptoms that lasted for six weeks after treatment cessation. This case highlights the need for further research to identify the underlying mechanisms, high-risk populations, and implications for informed consent and clinical recommendations.