Longitudinal assessment of structural and locomotor deficits as a prediction of severity in the collagenase-induced mouse model of osteoarthritis
Open-field quantification of kinetic parameters is a simple and timely relevant test to detect early locomotor changes and predict histological changes. Meniscal calcifications and osteophyte formation, which can be observed by µCT at early time points, are also highly predictive of OA severity. These two non-invasive techniques are very useful for longitudinal monitoring of mice and OA score prediction.
Authors
- Anne-Laure Mausset-Bonnefont (ORCID: https://orcid.org/0000-0003-4119-1475)
- Danièle Noël (ORCID: https://orcid.org/0000-0002-3498-3776)
- Christian Jørgensen (ORCID: https://orcid.org/0000-0001-6947-8094)
- Karine Toupet (ORCID: https://orcid.org/0000-0002-4372-8064)
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s13075-025-03507-w
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Université de Montpellier