Preventing Intravenous Acetaminophen and Propacetamol Induced Serious Hypotension

Background : Seoul St. Mary's Hospital has been working as a Regional Pharmacovigilance Center, collecting, evaluating, and reporting adverse drug reactions (ADRs).Recently, as a result of serious adverse drug reaction monitoring, it has been confirmed that hypotension caused by intravenous acetaminophen and propacetamol is rapidly increased.This study aimed to analyze current status of hypotension caused by intravenous acetaminophen and propacetamol and conduct prevention activities to reduce serious hypotension ADR. Methods :From August 2022 to January 2023, ADR evaluation data and electronic medical records were retrospectively reviewed for ADR reports in which adverse event was described as 'hypotension' or 'blood pressure decreased' after administration of intravenous acetaminophen and propacetamol.Educational materials for preventing critical hypotension were also produced.Results : There were 67 cases of hypotensive ADRs reported by intravenous acetaminophen and propacetamol administration.Serious ADRs (13 cases) accounted for 19.4%.Among patients with serious hypotension, 6 cases caused by acetaminophen and 7 cases caused by propacetamol were reported, with hypotension incidence of 0.7% and 0.8%, respectively.There was no gender difference.The average age was 59.0 years.Eleven patients were accompanied by sepsis and septic shock.Based on these results, we