Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex‐specific manner
Cognitively impaired (CI) patients exhibited lower metabotropic glutamate receptor 5 (mGluR5) availability in the hippocampus than cognitively unimpaired (CU) subjects. Hippocampal mGluR5 availability was negatively associated with tau deposition in widespread cortex. Hippocampal mGluR5 availability was positively associated with cognitive performance. The close association of mGluR5 with tau and cognition performance exists only in females. Tau pathology mediated the relationship between mGluR5 availability and cognition.
Authors
- Tengfei Guo (ORCID: https://orcid.org/0000-0003-2982-0865)
- Fang Xie (ORCID: https://orcid.org/0000-0003-2667-281X)
- Ruiqing Ni (ORCID: https://orcid.org/0000-0002-0793-2113)
- Yihui Guan (ORCID: https://orcid.org/0000-0003-3001-7965)
- Binyin Li (ORCID: https://orcid.org/0000-0003-1953-382X)
- Zhiwen You
- Qi Huang (ORCID: https://orcid.org/0000-0002-9425-6618)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-3128-6596)
- Jie Wang (ORCID: https://orcid.org/0000-0001-5259-7054)
- Xing Chen (ORCID: https://orcid.org/0009-0007-3479-1962)
- Kun He (ORCID: https://orcid.org/0000-0002-6969-3488)
- Zengping Lin
- Yan Wang (ORCID: https://orcid.org/0009-0006-5196-4581)
Institutions
- Shanghai Jiao Tong University (CN)
- University of Zurich (CH)
- Fudan University (CN)
- Ruijin Hospital (CN)
- ETH Zurich (CH)
- Institute for Biomedical Engineering (CH)
- Shenzhen Bay Laboratory (CN)
- Shanghai East Hospital (CN)
- United Imaging Healthcare (China) (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.70004
- Citations
- 9
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 8.18
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Fudan University
- Huashan Hospital