Population-based study of recurrent DNA damage response gene variants in breast cancer cases
The studied DDR gene variants were present in 9% of the unselected cases. As the presence of germline pathogenic variants can provide additional value for surgical decision-making and affect the choice of oncological treatments, the results promote the benefits of genetic testing as a part of breast cancer diagnostics.
Authors
- Katri Pylkäs (ORCID: https://orcid.org/0000-0002-2449-0521)
- Robert Winqvist (ORCID: https://orcid.org/0000-0003-0932-9104)
- Susanna Koivuluoma (ORCID: https://orcid.org/0009-0008-5362-4307)
- Anna Tervasmäki (ORCID: https://orcid.org/0000-0002-0687-2120)
- Timo A. Kumpula (ORCID: https://orcid.org/0000-0002-6124-8929)
- Mervi Grip
- Tuomo Mantere (ORCID: https://orcid.org/0000-0003-3284-4403)
- Meeri Seuranen
Institutions
- Oulu University Hospital (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1007/s10549-025-07634-5
- Citations
- 3
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Academy of Finland
- Oulun Yliopisto
- Biocenter, University of Oulu