Regulation of CXCR4 function by S1P1 through heteromerization
This study identifies CXCR4-S1P<sub>1</sub> heteromers and demonstrates a unidirectional modulation of CXCR4 by S1P<sub>1</sub>. S1P<sub>1</sub> affects CXCR4 function by disrupting its G protein pre-association and oligomerization. These findings underscore the regulatory role of the S1P/S1P<sub>1</sub> axis in CXCR4 signaling within the heteromeric context and provide novel insights into the intricate mechanisms governing immune cell trafficking.
Authors
- Won‐Ki Huh (ORCID: https://orcid.org/0000-0002-9091-6594)
- Hyun-Tae Kim (ORCID: https://orcid.org/0000-0001-5124-7976)
- Jae-Yeon Jeong
Institutions
- Seoul National University (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s12964-025-02099-x
- Citations
- 5
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Research Foundation of Korea