Association between serum vitamin A and bone mineral density in adolescents

Vitamin A is essential for growth and development, immune function, vision, and gene expression. The association between adult bone mineral density (BMD) and vitamin A has been extensively studied, the findings are heterogeneous. Studies investigating the direct correlation between vitamin A and BMD in children are, nonetheless, few. The purpose of this study is to investigate the link between vitamin A and BMD in American teenagers. In this cross-sectional investigation, 6,002 adolescents between the ages of 12 and 19 participated in the National Health and Nutrition Examination Survey (NHANES), which was performed between 2001 and 2006. The relationship between serum Vitamin A and BMD was assessed using a weighted multivariate linear regression model and smooth-fitting curves. Increased serum Vitamin A is substantially positively linked with BMD of the thoracic spine, lumbar spine, pelvis, trunk bone, and total BMD after controlling for pertinent factors. According to the threshold effect curve, the impact of Vitamin A is significant (P < 0.05) when it is below the saturation threshold. Males exhibit a stronger positive association, according to subgroup analysis. According to our research, there is a strong positive connection and saturation effect between serum Vitamin A and BMD in American adolescents.