Comparative effectiveness and prescribing trends of modified release versus immediate release indapamide in patients with hypertension: cohort study
In patients treated with indapamide for hypertension, starting treatment with modified release or immediate release indapamide had similar risks for cardiovascular events or all cause mortality. In an exploratory secondary analysis, sustained treatment with modified release preparations was associated with a lower the risk of cardiovascular events but not all cause mortality compared with immediate release preparations. These findings need to be confirmed in prospective studies.
Authors
- Bryan Williams (ORCID: https://orcid.org/0000-0002-8094-1841)
- Esther W. Chan (ORCID: https://orcid.org/0000-0002-7602-9470)
- Chengsheng Ju (ORCID: https://orcid.org/0000-0001-7860-6262)
- Isla S. Mackenzie (ORCID: https://orcid.org/0000-0002-3680-7127)
- Vincent Ka Chun Yan (ORCID: https://orcid.org/0000-0001-5225-3032)
- Thomas M. MacDonald
- George Casella (ORCID: https://orcid.org/0000-0001-8154-8278)
- Yang Chen (ORCID: https://orcid.org/0000-0001-6032-3387)
- Li Wei (ORCID: https://orcid.org/0000-0001-8840-7267)
- R. W. V. Flynn
Institutions
- Department of Health (CN)
- University College London Hospitals NHS Foundation Trust (GB)
- University of Dundee (GB)
- National Institute for Health and Care Excellence (GB)
- National Institute for Health and Care Research (GB)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Institut de Recherche et d’Innovation (FR)
- University College London (GB)
- University of Hong Kong (HK)
Publication Details
- Journal
- BMJ Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/bmjmed-2024-000857
- Citations
- 2
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Amgen
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- Wellcome Trust
- Diabetes UK
- Pharmacy Research UK
- Innovation and Technology Commission
- Food and Health Bureau
- Medical Research Council
- National Health and Medical Research Council