JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis
Taken together, we elucidated the JMJD6 acetylation/METTL14/m6A/SLC3A2 axis as a key mediator of lung cancer progression, indicating that JMJD6 may serve as a potentially prognostic biomarker and therapeutic target for NSCLC.
Authors
- Chenxing Zhang
- Junhu Wan (ORCID: https://orcid.org/0009-0008-3869-7153)
- Nan Xiao (ORCID: https://orcid.org/0000-0002-0754-2609)
- Qiaozhen Kang
- Yang Li (ORCID: https://orcid.org/0000-0001-9055-2332)
- Hongyang Liu (ORCID: https://orcid.org/0000-0002-8053-535X)
- Xiangzhuan Zhao
- Lu Bai
- Huanxiang Chen
- Ruike Zhang (ORCID: https://orcid.org/0009-0008-8686-3793)
Institutions
- Zhengzhou University (CN)
- Shangqiu First People's Hospital (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s12967-025-06241-8
- Citations
- 13
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province
- Henan Provincial Science and Technology Research Project