Plasma Proteomic Assessment of Calcific Aortic Valve Disease in Older Adults
This study of older adults newly identified and largely replicated associations of 3 circulating proteins with calcific aortic valve disease, of which the relationship of plasma KLKB1 may have a causal basis. Additional investigation is necessary to determine if KLKB1 could be harnessed for calcific aortic valve disease therapeutics.
Authors
- Vilmundur Guðnason (ORCID: https://orcid.org/0000-0001-5696-0084)
- Valborg Guðmundsdóttir (ORCID: https://orcid.org/0000-0002-7459-1603)
- Bruce M. Psaty (ORCID: https://orcid.org/0000-0002-7278-2190)
- Lori L. Jennings (ORCID: https://orcid.org/0000-0001-5130-8417)
- Daniele Massera (ORCID: https://orcid.org/0000-0002-9499-6456)
- George Thanassoulis (ORCID: https://orcid.org/0000-0002-9930-7189)
- Jorge R. Kizer (ORCID: https://orcid.org/0000-0001-9936-7803)
- Russell P. Tracy (ORCID: https://orcid.org/0000-0002-0080-2420)
- Robert E. Gerszten (ORCID: https://orcid.org/0000-0002-6767-7687)
- Thomas R. Austin
- Line Dufresne (ORCID: https://orcid.org/0000-0001-6923-8517)
- Valur Emilsson (ORCID: https://orcid.org/0000-0001-9982-0524)
- Anna E. Bortnick (ORCID: https://orcid.org/0000-0001-7983-5243)
- James C. Engert (ORCID: https://orcid.org/0000-0001-8411-4790)
- David S. Owens (ORCID: https://orcid.org/0000-0002-7293-9688)
- Ta‐Yu Yang (ORCID: https://orcid.org/0000-0002-5379-5340)
- Emily Hamerton
Institutions
- University of Vermont (US)
- Albert Einstein College of Medicine (US)
- Beth Israel Deaconess Medical Center (US)
- Montefiore Medical Center (US)
- Harvard University (US)
- University of Iceland (IS)
- University of California, San Francisco (US)
- University of Washington (US)
- Beth Israel Deaconess Hospital (US)
- McGill University Health Centre (CA)
- NYU Langone Health (US)
- Novartis (China) (CN)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Novartis (United States) (US)
- San Francisco VA Health Care System (US)
- Icelandic Heart Association (IS)
- McGill University (CA)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1161/jaha.124.036336
- Citations
- 4
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.55