Genome‐Wide Association Study for Resting Electrocardiogram in the Qatari Population Identifies 6 Novel Genes and Validates Novel Polygenic Risk Scores
In this first genome-wide association study for ECG traits in the Middle East using whole-genome sequence data, 7 novel loci (6 genes) were identified. Published PRSs performed well, but newly developed Middle Eastern-specific PRSs performed the best. Novel variants in long QT syndrome genes were observed for the first time in Qatari individuals. Follow-up data did not show significant changes in ECG patterns.
Authors
- Georges Nemer (ORCID: https://orcid.org/0000-0003-2157-5279)
- Atlas Khan (ORCID: https://orcid.org/0000-0002-6651-2725)
- Nahin Khan (ORCID: https://orcid.org/0000-0002-0645-9993)
- Ayman Al Haj Zen (ORCID: https://orcid.org/0000-0002-2145-2925)
- Krzysztof Kiryluk (ORCID: https://orcid.org/0000-0002-5047-6715)
- Mohamed Elshrif (ORCID: https://orcid.org/0000-0003-0092-8258)
- Mohamad Saad (ORCID: https://orcid.org/0000-0001-6357-8502)
- Khalid Kunji (ORCID: https://orcid.org/0000-0003-2946-512X)
- Abdulkader Shaar (ORCID: https://orcid.org/0000-0002-2961-7501)
- Mohammed Bashir (ORCID: https://orcid.org/0000-0003-3096-2641)
- Akl C. Fahed (ORCID: https://orcid.org/0000-0002-4849-6389)
- Mohammed T. Ali (ORCID: https://orcid.org/0000-0002-8318-4858)
Institutions
- Broad Institute (US)
- Harvard University (US)
- Khalifa University of Science and Technology (AE)
- Massachusetts General Hospital (US)
- University College Hospital at Westmoreland Street (GB)
- Hamad bin Khalifa University (QA)
- Columbia College (CA)
- Health & Life (Taiwan) (TW)
- Royal College of Physicians (GB)
- University College London (GB)
- Hamad Medical Corporation (QA)
- Columbia University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1161/jaha.124.038341
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82