Identification of Bioactive Metabolites of Capirona macrophylla by Metabolomic Analysis, Molecular Docking, and In Vitro Antiparasitic Assays
The ethnobotanical use of "mulateiro" wood bark tea as an antimalarial and antileishmanial agent was confirmed through in vitro assays. We speculate that these activities are attributed to linoleic acids and quinic acids.
Authors
- Carolina García (ORCID: https://orcid.org/0000-0003-1907-036X)
- Sheila Barreto Guterres
- Geisa Paulino Caprini Evaristo
- Welington da Silva Paula do Nascimento (ORCID: https://orcid.org/0000-0001-6935-952X)
- Fábio César Sousa Nogueira (ORCID: https://orcid.org/0000-0001-5507-7142)
- Joseph Albert Medeiros Evaristo (ORCID: https://orcid.org/0000-0001-5401-1758)
- Estella Aparecida De Laia
- Fernando Berton Zanchi (ORCID: https://orcid.org/0000-0003-3386-0069)
- Caroline Rodrigues
- Esdras Abimael Maia Mendonça
- Bruna de Souza Tavares
- Larissa Grisostenes
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal de Rondônia (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Metabolites
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3390/metabo15030157
- Citations
- 1
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Universidad Internacional de La Rioja
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Ministério da Saúde
- Fundação Oswaldo Cruz
- Universidade Federal do Rio de Janeiro
- Foundation for Scientific and Technological Development in Health