RORγt Mediates Angiotensin II‐Induced Pressor Responses, Microglia Activation, and Neuroinflammation by Disrupting the Blood–Brain Barrier in Rats
These findings suggest that RORγt inhibition reduces neuroinflammation and sympathetic activation to ameliorate ANG II-induced hypertension, likely by mitigating IL-17A-induced BBB disruption and microglial activation in the paraventricular nucleus.
Authors
- Alexander G. Bassuk (ORCID: https://orcid.org/0000-0002-4067-2157)
- Alan Kim Johnson (ORCID: https://orcid.org/0000-0002-6997-161X)
- Baojian Xue (ORCID: https://orcid.org/0000-0002-6326-0075)
- Yang Yu (ORCID: https://orcid.org/0000-0001-8419-2270)
- Shun‐Guang Wei (ORCID: https://orcid.org/0000-0003-4404-4059)
- Lei Tong (ORCID: https://orcid.org/0000-0003-2626-4162)
Institutions
- University of Iowa (US)
- Iowa City VA Medical Center (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1161/jaha.124.040461
- Citations
- 4
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 3.19