Right Ventricular Stiffening and Anisotropy Alterations in Pulmonary Hypertension: Mechanisms and Relations to Right Heart Failure
Multiscale biomechanical analysis indicated that, although hypertrophy and fibrosis occur in both mild and severe PH, certain fiber-level remodeling events, including increased tautness of collagen fibers and significant reorientations of myofibers, contributed to excessive biomechanical maladaptation of the RVFW leading to severe RV-pulmonary artery uncoupling. Collagen fiber remodeling and the loss of tissue anisotropy can provide an improved understanding of the transition from adaptive to maladaptive RV remodeling.
Authors
- Tasnim F. Imran (ORCID: https://orcid.org/0000-0003-2089-8244)
- Gaurav Choudhary (ORCID: https://orcid.org/0000-0001-9343-5481)
- Reza Avazmohammadi (ORCID: https://orcid.org/0000-0001-9787-1117)
- Alexander Vang (ORCID: https://orcid.org/0000-0001-5691-781X)
- Preston N. Nicely (ORCID: https://orcid.org/0000-0002-0374-6612)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-0190-5384)
- Sunder Neelakantan (ORCID: https://orcid.org/0000-0002-5445-4070)
- Haley Phelan (ORCID: https://orcid.org/0000-0002-3230-7731)
- Rana Raza Mehdi (ORCID: https://orcid.org/0000-0002-9008-9058)
Institutions
- Houston Methodist (US)
- Brown University (US)
- Mitchell Institute (US)
- Providence VA Medical Center (US)
- Texas A&M University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1161/jaha.124.037126
- Citations
- 19
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 28.85