Protein Drug Targets for Abdominal Aortic Aneurysm and Proteomic Associations Between Modifiable Risk Factors and Abdominal Aortic Aneurysm
This analysis identifies 4 proteins (PCSK9, IL6R, ECM1, and ANGPTL4) as high-priority therapeutic targets for AAA and emphasizes the intermediary role of plasma proteins in linking hypertension, smoking, obesity, and AAA. Further investigations are needed to clarify the specific roles of these proteins in AAA pathology.
Authors
- Yu Lun (ORCID: https://orcid.org/0000-0001-5165-247X)
- Han Zhang (ORCID: https://orcid.org/0000-0002-5333-3322)
- Mingyu Liu (ORCID: https://orcid.org/0009-0008-2564-5258)
- Han Jiang (ORCID: https://orcid.org/0000-0002-4278-6617)
- Qingwei Gang
- Jian Zhang (ORCID: https://orcid.org/0000-0003-4448-0774)
- Yixian Wang (ORCID: https://orcid.org/0000-0001-8669-7598)
- Qi Yao (ORCID: https://orcid.org/0000-0002-4146-0914)
- Shikai Shen
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1161/jaha.124.037802
- Citations
- 2
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04