Hydroxychalcones as Herbicides

Efforts to develop weed management alternatives are urgently required due to various challenges, such as declining crop yields, rising production costs, and the growing prevalence of herbicide-resistant weed species. Chalcones occur in nature and have phytotoxic potential and concise synthesis; additionally, they are multifunctional, with diverse biomolecular targets and a broad spectrum of biological activities. This study sought to assess the herbicidal potential of 3?-hydroxychalcones against weed species under laboratory conditions. Their effects were investigated using germination bioassays, early growth measurements, and the seedling vigor index, all prepared with a concentration of 1 × 10?3 mol L?1 3?-hydroxychalcones. 3?-Hydroxy-4-pyridyl-chalcone caused the greatest inhibition (81%) of the seedling length in Urochloa decumbens. Other 3?-hydroxychalcones also caused large initial growth reductions, such as 3?-hydroxy-4-pyridyl-chalcone (75%) and 3?-hydroxy-4-nitrochalcone (68%) in Digitaria insularis and 3?-hydroxy-4-bromochalcone (73%) in Raphanus raphanistrum. The greatest reduction in the seedling vigor index was 81% in D. insularis treated with the 3?-hydroxy-4-bromochalcone. The same 3?-hydroxychalcone caused an 80% reduction in Amaranthus viridis. In conclusion, 3?-hydroxychalcones exhibit herbicidal activity, suggesting they could serve as a solution for future weed management strategies.