Asymmetric Hydrogenation of Polysubstituted Isoquinolines with Chiral Boranes
This paper describes an asymmetric hydrogenation of 1,3-disubstituted isoquinolines catalyzed by chiral borane derived from chiral alkene, giving the desired <i>cis</i>-products in high yields with up to 96% ee. In particular, the asymmetric hydrogenation of challenging 1,3,4-trisubstituted isoquinolines could proceed smoothly to afford the corresponding products in high yields with moderate ee's for the first time.
Authors
- Xiangqing Feng (ORCID: https://orcid.org/0000-0003-1739-925X)
- Fuqu Zou
- Haifeng Du (ORCID: https://orcid.org/0000-0003-0122-3735)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1021/acs.orglett.5c00272
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China