An Approach to Enhance the Solubility of an Atypical Antipsychotic Drug, Aripiprazole: Design, Characterization, and Evaluation of Arabinoxylan-Based Nanoparticles
The AX-based nanoparticle formulation significantly improved the solubility, pH-dependent release profile, and sustained release of APZ, offering a promising strategy to enhance the oral bioavailability of poorly soluble drugs. These findings suggest that AX nanoparticles could serve as an effective delivery system for enhancing the therapeutic potential of hydrophobic drugs like APZ.
Authors
- Ume Ruqia Tulain (ORCID: https://orcid.org/0000-0003-3771-1466)
- Alia Erum (ORCID: https://orcid.org/0000-0002-4092-3120)
- Mohammed S. Alqahtani (ORCID: https://orcid.org/0000-0002-5027-6545)
- Nadia Shamshad Malik (ORCID: https://orcid.org/0000-0002-0474-3448)
- Mehwish Sikander
- Arshad Mahmood
- Muhammad Tariq Khan (ORCID: https://orcid.org/0000-0002-1793-4155)
Institutions
- Quaid-i-Azam University (PK)
- University of Sargodha (PK)
- Al Ain University (AE)
- King Saud University (SA)
- Capital University of Science and Technology (PK)
Publication Details
- Journal
- Nanotechnology Science and Applications
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/nsa.s502002
- Citations
- 1
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.79