IL-8–NF-κB–ALDH1A1 loop promotes the progression of intrahepatic cholangiocarcinoma
IL-8-derived tumor cells could upregulate ALDH1A1 expression by activating the NF-κB signaling pathway, promoting tumor progression. Upregulation of ALDH1A1 could activate NF-κB to promote IL-8 secretion, forming a positive feedback loop to promote tumor invasiveness and cell stemness in ICC.
Authors
- Yueren Wang
- Qiyue Hu (ORCID: https://orcid.org/0009-0001-1701-8608)
- Yufeng Li (ORCID: https://orcid.org/0009-0001-1664-5562)
- Chuang Peng (ORCID: https://orcid.org/0000-0002-3701-1737)
- Yinghui Song (ORCID: https://orcid.org/0000-0002-6592-6678)
- Feicheng Yang
- Sulai Liu (ORCID: https://orcid.org/0000-0002-5257-3922)
- Yuewei Tao (ORCID: https://orcid.org/0000-0002-8059-8000)
- Yizhi Wang (ORCID: https://orcid.org/0000-0001-5279-5034)
- Zexi Yin
- Xinling Zhang (ORCID: https://orcid.org/0000-0003-3783-0465)
- Jianfeng Yu (ORCID: https://orcid.org/0000-0003-0082-5427)
- Jia Zhou (ORCID: https://orcid.org/0000-0002-5567-9968)
Institutions
- Hunan Normal University (CN)
- University of Dundee (GB)
- Ninewells Hospital (GB)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1097/hc9.0000000000000664
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87