Population-specific genetic-risk scores enable improved prediction of mortality within 28 days of sepsis onset: a retrospective Taiwanese cohort study
This study proposed genetic-risk models specific for Taiwanese populations that outperformed clinical-only models. Also it established a strong racial-effect on the underlying genetics of sepsis-related mortality. The model can potentially be used in real clinical setting for deciding precise treatment courses for patients at high-risk thereby reducing the possibility of worse outcomes.
Authors
- Shu‐Hui Liao
- Tzu‐Pin Lu (ORCID: https://orcid.org/0000-0003-3697-0386)
- C Y Chen
- Amrita Chattopadhyay (ORCID: https://orcid.org/0000-0001-5591-7674)
- Kuan-Chih Chiu
- Ming‐Shun Hsieh (ORCID: https://orcid.org/0000-0003-2734-392X)
- Chorng–Kuang How (ORCID: https://orcid.org/0000-0002-7419-0797)
- Yi‐Ming Chen (ORCID: https://orcid.org/0000-0001-7593-3065)
- Tzu‐Hung Hsiao (ORCID: https://orcid.org/0000-0003-0365-9970)
- Sung-Yuan Hu (ORCID: https://orcid.org/0000-0002-7577-4022)
- Pei‐Hsuan Wu
Institutions
- Fu Jen Catholic University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Chung Hsing University (TW)
- National Taiwan University (TW)
- National Taipei University of Nursing and Health Science (TW)
- National Tsing Hua University (TW)
- Taipei Veterans General Hospital (TW)
- Taichung Veterans General Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Journal of Intensive Care
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s40560-025-00783-1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academia Sinica