Intestinal 8 gingerol attenuates TBI-induced neuroinflammation by inhibiting microglia NLRP3 inflammasome activation in a PINK1/Parkin-dependent manner
our findings shed light on the pivotal role of gut microbes in TBI, and identify 8 gingerol as an important anti-inflammatory compound during TBI.
Authors
- Zhenhua Zeng (ORCID: https://orcid.org/0000-0002-9509-1536)
- Fei Zhou (ORCID: https://orcid.org/0000-0003-1857-8831)
- Hongyuan Yang (ORCID: https://orcid.org/0000-0002-8482-6031)
- Na Qin (ORCID: https://orcid.org/0009-0001-2399-3514)
- Fen Li (ORCID: https://orcid.org/0000-0002-0162-2595)
- Weiquan Ma (ORCID: https://orcid.org/0000-0003-3951-4204)
- Huang Mingxin (ORCID: https://orcid.org/0000-0002-3351-7001)
- Shenhai Gong (ORCID: https://orcid.org/0000-0002-1366-6894)
- Yiqin Yu
- Lin Huang (ORCID: https://orcid.org/0000-0001-8646-1921)
- Xuheng Tang
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.phymed.2025.156580
- Citations
- 9
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangdong Medical Research Foundation