Gold Nanoparticles Functionalized With 5-Amino-2-Mercaptobenzimidazole: A Promising Antimicrobial Strategy Against Carbapenem-Resistant Gram-Negative Bacteria
5-A-2MBI_Au NPs are a novel and highly effective antibacterial agent prepared through a simple process using benzimidazole and HAuCl<sub>4</sub>•3H<sub>2</sub>O. They efficiently eradicate the most challenging multidrug-resistant GNB both in vitro and in vivo while demonstrating excellent biocompatibility. This highlights their potential as a promising antibacterial agent to combat multidrug-resistant GNB.
Authors
- Jianming Cao (ORCID: https://orcid.org/0000-0002-9968-6721)
- Tieli Zhou (ORCID: https://orcid.org/0000-0002-2171-4710)
- Zhuocheng Yao (ORCID: https://orcid.org/0000-0002-2167-6611)
- Xiaotuan Zhang (ORCID: https://orcid.org/0000-0002-2697-3885)
- Ping Xia
- Jianzhong Ye (ORCID: https://orcid.org/0000-0001-8174-2580)
- Jia Zhang (ORCID: https://orcid.org/0000-0003-4628-0215)
- Juan Pan
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijn.s502139
- Citations
- 7
- Primary Topic
- Antibiotic Use and Resistance
- Type
- article
- Field-Weighted Citation Impact
- 8.83