Down-regulation of PCK2 enhanced the radioresistance phenotype of nasopharyngeal carcinoma
Our findings indicate that low expression of PCK2 is an important phenotypic feature of radioresistant NPC cells. It could be a result of PCK2 involved in regulating radiation-induced ferroptosis. Regulating the expression of PCK2 may provide new strategies for improving NPC radiation sensitivity.
Authors
- Zhaolu Kong (ORCID: https://orcid.org/0000-0003-4334-4746)
- Wang Xiao-sheng
- Yijun He (ORCID: https://orcid.org/0000-0003-1152-2907)
- Ruiqi Zhang (ORCID: https://orcid.org/0000-0002-5517-6789)
- Yan Li (ORCID: https://orcid.org/0000-0002-3209-4465)
- Rui Yang (ORCID: https://orcid.org/0000-0003-1801-6134)
Institutions
- Fudan University (CN)
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1080/09553002.2025.2470226
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China