Thymidine kinase 1 indicates resistance to immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma
High-TK1 expression could be a potential indicator for therapeutic resistance, poor PFS and immune evasion in metastatic RCC under IO + TKI therapy. The novel RF risk score may help stratify patients for IO + TKI therapy.
Authors
- Yanjun Zhu (ORCID: https://orcid.org/0000-0001-8574-6351)
- Xianglai Xu (ORCID: https://orcid.org/0000-0001-7433-8694)
- Jiajun Wang (ORCID: https://orcid.org/0000-0003-3115-7425)
- Ying Wang (ORCID: https://orcid.org/0000-0002-8566-875X)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1007/s13402-025-01048-7
- Citations
- 3
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Natural Science Foundation of Shanghai
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province