Structural, microstructural, dielectric, mechanical properties of PVDF/HAP nanocomposite films for bone regeneration applications

Poly(vinylidene fluoride) (PVDF)/hydroxyapatite (HAP) nanocomposite films, incorporating HAP nanoparticles as filler within a PVDF matrix, were successfully synthesized by solution casting method. Increasing the HAP concentration in the nanocomposite significantly enhances its electroactive properties, with synergistic effects on surface, electrical and biological characteristics are investigated comprehensively. Improvements in topographical and mechanical parameters reveal the nanocomposite films for biomimetic suitability. Notably, the impact of dielectric and ferroelectric properties on biological studies is well established. With increasing the HAP concentration, we observed significant improvements in remnant polarization from 0.28 to 1.87 µC cm^-2, saturation polarization from 1.1 to 2.10 µC cm^-2, and coercive field from 88.55 to 243.65 kV cm^-1. In<i>in-vitro</i>experiments with osteosarcoma cells, the nanocomposite films with 40% HAP showed higher cell proliferation and viability. Present finding indicated 60PVDF/40HAP nanocomposite films as a biomimicry candidate for bone regeneration applications.