A proinflammatory response and polarized differentiation of stromal elements characterizes the murine myeloma bone marrow niche
MM cells impact the BM niche by generating a pro-inflammatory microenvironment with MSC differentiation being changed to generate cell subsets that favor MM growth and survival. In order to induce remission and improve long-term outcome for MM patients these inflammatory and oxidative stress signals need to be reduced and normal niche differentiation trajectories restored.
Authors
- Yubao Wang (ORCID: https://orcid.org/0000-0002-8063-6628)
- Eileen M. Boyle (ORCID: https://orcid.org/0000-0001-8791-1744)
- Dylan Gagler (ORCID: https://orcid.org/0000-0003-0333-3989)
- Faith E. Davies (ORCID: https://orcid.org/0000-0002-3971-2393)
- Aristotelis Tsirigos (ORCID: https://orcid.org/0000-0002-7512-8477)
- Patrick Blaney (ORCID: https://orcid.org/0000-0002-9319-8866)
- Hussein Ghamlouch (ORCID: https://orcid.org/0000-0002-2932-1081)
- Ola Landgren
- Francesco Maura (ORCID: https://orcid.org/0000-0002-5017-1620)
- Jason Avigan (ORCID: https://orcid.org/0009-0003-2470-5451)
- Gareth J. Morgan (ORCID: https://orcid.org/0000-0002-4271-6360)
- Jinyoung Choi
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- University of Miami (US)
- NYU Langone Health (US)
- Sylvester Comprehensive Cancer Center (US)
- University College London (GB)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s40164-025-00606-x
- Citations
- 5
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- NYU Langone Medical Center
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems