Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis
FT3 levels in early pregnancy were positively associated with the risk of GDM, and MR analysis provided evidence supporting a causal relationship. However, future studies are required to further investigate this association through larger-scale GWAS in diverse ethnic populations and to explore the underlying biological mechanisms.
Authors
- Jianxia Fan (ORCID: https://orcid.org/0000-0003-3338-877X)
- Haixia Guan (ORCID: https://orcid.org/0000-0003-3155-2847)
- Yong Zhang (ORCID: https://orcid.org/0000-0003-1436-5951)
- Zixuan Huang (ORCID: https://orcid.org/0000-0002-5028-4684)
- Shuai Yang (ORCID: https://orcid.org/0000-0002-1353-2941)
- Yanan Li (ORCID: https://orcid.org/0000-0003-4396-0557)
Institutions
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Shanghai Municipal People's Government (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s12986-025-00905-4
- Citations
- 4
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- National Natural Science Foundation of China