METTL3 enhances esophageal squamous cell carcinoma progression by suppressing ferroptosis through the PBX3/CA9 cascade
Our study elucidates a novel mechanism, the METTL3/PBX3/CA9 cascade, underlying the oncogenic activity of METTL3 in ESCC. The novel cascade may represent the potential target for ESCC therapy in the future.
Authors
- Min Tuo
- Chunming Ding (ORCID: https://orcid.org/0000-0002-2063-5594)
- Ping Liu (ORCID: https://orcid.org/0000-0002-0292-8107)
- T. Ming Chu
- Lingxia Yang (ORCID: https://orcid.org/0000-0002-9569-2104)
Institutions
- First People’s Hospital of Jingmen (CN)
Publication Details
- Journal
- Pathology - Research and Practice
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.prp.2025.155865
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00