Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis
In conclusion, our results suggested that UPR/NLRP3 inflammasome-mediated pyroptosis/apoptosis pathway was involved in diabetic podocyte injury, and that targeting the CHOP-TXNIP axis may serve as a promising therapeutic target for DKD.
Authors
- Jiali Wei
- Langtao Hu
- Huafeng Liu (ORCID: https://orcid.org/0000-0001-6547-212X)
- Ruike Chen
- Yao Chen (ORCID: https://orcid.org/0000-0002-2336-3432)
- Yun Cao
Institutions
- Guangdong Medical College (CN)
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.cellsig.2025.111702
- Citations
- 18
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 14.51
Funders
- National Natural Science Foundation of China