Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells
This study demonstrates that PAS prevents peritoneal adhesions via RNS-mediated eNOS restoration, suppressing oxidative stress, apoptosis, and MMT. These findings position PAS as a novel and promising therapy for adhesion prevention, warranting clinical translation.
Authors
- Chengxue Dang (ORCID: https://orcid.org/0000-0002-2934-7337)
- Yuyi Ma
- Yu-Ping Peng (ORCID: https://orcid.org/0000-0002-5966-0922)
- Nan Hao (ORCID: https://orcid.org/0000-0003-2857-4789)
- Zhangjian Zhou (ORCID: https://orcid.org/0000-0002-2341-6338)
- Tianhao Min
- Guimin Xu (ORCID: https://orcid.org/0000-0001-8185-5446)
- Xiaoyuan Deng (ORCID: https://orcid.org/0000-0002-5204-0384)
- Kaijie Ren (ORCID: https://orcid.org/0000-0003-0314-8943)
- Y. C. Nan (ORCID: https://orcid.org/0000-0002-7363-0252)
- Tuanhe Sun (ORCID: https://orcid.org/0000-0002-1401-6914)
- Guanjun Zhang (ORCID: https://orcid.org/0000-0003-1859-0443)
- Xueni Wang (ORCID: https://orcid.org/0000-0001-9884-994X)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-2464-1422)
- Shuo Li (ORCID: https://orcid.org/0000-0002-5184-3230)
- Wei Wang
- Hao Zhang
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0002-2097-5708)
- Xin Xie
- Kun Zhu (ORCID: https://orcid.org/0000-0002-9664-6927)
- Yue Yuan (ORCID: https://orcid.org/0000-0003-3980-0630)
- Rulan Ma
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.jare.2025.02.024
- Citations
- 2
- Primary Topic
- Intestinal and Peritoneal Adhesions
- Type
- article
- Field-Weighted Citation Impact
- 4.01