Interleukin-36β inhibits CD4+CD25+ regulatory T cells by activating endoplasmic reticulum-phagy in septic mice
IL-36β can down-regulate the immune activity of CD4<sup>+</sup>CD25<sup>+</sup> Tregs via ER-phagy induction. Our study might provide novel targets for therapeutic strategies to prevent the development of sepsis.
Authors
- Xi Chen (ORCID: https://orcid.org/0000-0002-3958-6905)
- Yun Ge
Institutions
- Hangzhou Medical College (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.intimp.2025.114349
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China