Optogenetic cortical spreading depression originating from the primary visual cortex induces migraine-like pain and anxiety behaviors in freely moving C57BL/6 J mice
This study proposes an optogenetic CSD-induced migraine model originating from VISp in awake and freely moving C57BL/6 J mice and presents the behavioral paradigm in detail. The CSD model in wild-type mice is promising to be wildly used to study the pathogenesis of MwA.
Authors
- Chenghui Pi (ORCID: https://orcid.org/0000-0001-6845-4031)
- Bozhi Li (ORCID: https://orcid.org/0000-0003-4408-5416)
- Ruozhuo Liu (ORCID: https://orcid.org/0000-0001-8582-580X)
- Wei Xie (ORCID: https://orcid.org/0000-0002-9179-4787)
- Shengyuan Yu (ORCID: https://orcid.org/0000-0001-8933-088X)
- Weinan Na
- Tao Wang (ORCID: https://orcid.org/0000-0002-7275-3293)
- Kang Li (ORCID: https://orcid.org/0000-0001-6507-7744)
- Chunxiao Yang (ORCID: https://orcid.org/0000-0003-2116-3354)
- Dengfa Zhao
- Shuai Miao
- Wenjing Tang (ORCID: https://orcid.org/0000-0002-2156-9795)
- Huijuan Yuan
- Deqi Zhai
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s10194-025-01983-8
- Citations
- 5
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- National Natural Science Foundation of China