People with four-class drug-resistant HIV-1 may have low levels of intact DNA

We evaluated the HIV-1 reservoir in people with four-class drug-resistant (4DR) virus compared with those without drug resistance. Using the intact proviral DNA assay, we found that both groups had similar levels of intact HIV-1 DNA, suggesting that multidrug-resistant HIV does not significantly alter the size of the reservoir. These findings are a first step in studying the HIV-1 reservoir in the population with multidrug-resistant virus, and further studies are needed to confirm our results.

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Publication Details

Journal
AIDS
Published
2025-02-26
DOI
https://doi.org/10.1097/qad.0000000000004066
Primary Topic
HIV Research and Treatment
Type
article
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article

People with four-class drug-resistant HIV-1 may have low levels of intact DNA

Maurizio Zazzi, Camilla Muccini, Daniela Cesana, Vincenzo Spagnuolo et al.
AIDS
HIV Research and Treatment
article

People with four-class drug-resistant HIV-1 may have low levels of intact DNA

Maurizio Zazzi, Camilla Muccini, Daniela Cesana, Vincenzo Spagnuolo, Antonella Castagna
article en

Abstract

We evaluated the HIV-1 reservoir in people with four-class drug-resistant (4DR) virus compared with those without drug resistance. Using the intact proviral DNA assay, we found that both groups had similar levels of intact HIV-1 DNA, suggesting that multidrug-resistant HIV does not significantly alter the size of the reservoir. These findings are a first step in studying the HIV-1 reservoir in the population with multidrug-resistant virus, and further studies are needed to confirm our results.

AIDSVol. 39(4)
University of Siena (IT), Vita-Salute San Raffaele University (IT), The San Raffaele Telethon Institute for Gene Therapy (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Good health and well-being
Openalex Percentile: Top 96%
HIV Research and Treatment
DOISourceOpenAlex
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People with four-class drug-resistant HIV-1 may have low levels of intact DNA — Maurizio Zazzi, Camilla Muccini, et al. · AIDS (2025) | TGRS Research Map | TGRS