Prognostic Impact of Early Appropriate Antimicrobial Therapy in Critically Ill Patients With Nosocomial Pneumonia Due to Gram-Negative Pathogens: A Multicenter Cohort Study
In this study, EAAT was not associated with a reduced day 28 mortality, a faster resolution of organ failure, a higher day 14 clinical cure rate, or a shorter time to MV weaning or ICU discharge in critically ill patients with HAP, vHAP, or VAP due to GNB. However, a prognostic benefit from EAAT cannot be ruled out due to lack of statistical power.
Authors
- Jean Reignier (ORCID: https://orcid.org/0000-0002-3768-3496)
- Claire Dupuis
- Yves Cohen (ORCID: https://orcid.org/0000-0001-6022-9366)
- Jean-Marie Forel (ORCID: https://orcid.org/0000-0002-1958-7388)
- Carole Schwebel (ORCID: https://orcid.org/0000-0003-1837-7415)
- Shidasp Siami (ORCID: https://orcid.org/0000-0002-0828-8403)
- Marc Gainnier (ORCID: https://orcid.org/0000-0002-5353-9275)
- Christophe Adrie
- Vivien Hong Tuan Ha (ORCID: https://orcid.org/0000-0003-0645-5455)
- François Barbier (ORCID: https://orcid.org/0000-0002-8447-7265)
- Jean‐Ralph Zahar (ORCID: https://orcid.org/0000-0002-4228-3868)
- Niccolò Buetti (ORCID: https://orcid.org/0000-0002-8096-1834)
- Élie Azoulay (ORCID: https://orcid.org/0000-0002-8162-1508)
- Étienne de Montmollin (ORCID: https://orcid.org/0000-0001-6379-1928)
- Jean-François Timsit
- Laurent Argaud
- Stéphane Ruckly
Institutions
- University of Geneva (CH)
- Inserm (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Hospices Civils de Lyon (FR)
- Centre Hospitalier Sud-Essonne Dourdan-Etampes (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Centre hospitalier universitaire d'Orléans (FR)
- Centre Hospitalier Saint-Denis (FR)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1097/ccm.0000000000006606
- Citations
- 3
- Primary Topic
- Nosocomial Infections in ICU
- Type
- article
- Field-Weighted Citation Impact
- 4.64