Genetic Correlates of Treatment-Resistant Depression
Results of this cohort study suggest that genetic predisposition related to neuroticism, cognitive function, and sleep patterns had a significant association with the development of TRD. These findings underscore the importance of considering psychosocial factors in managing and treating TRD. Future research should focus on integrating genetic data with clinical outcomes to enhance understanding of pathways leading to treatment resistance.
Authors
- Chun Chieh Fan (ORCID: https://orcid.org/0000-0001-9437-2128)
- Jonathan Ahern
- Robert Loughnan (ORCID: https://orcid.org/0000-0003-4870-4501)
- Rayus Kuplicki (ORCID: https://orcid.org/0000-0003-2954-6421)
- Charles B. Nemeroff (ORCID: https://orcid.org/0000-0001-7867-1160)
- Bohan Xu (ORCID: https://orcid.org/0000-0001-5876-1740)
- Martin P. Paulus (ORCID: https://orcid.org/0000-0002-0825-3606)
- Katherine L. Forthman (ORCID: https://orcid.org/0000-0002-8695-8388)
- Wesley K. Thompson
- Firas Naber
Institutions
- University of California San Diego (US)
- Human Longevity (United States) (US)
- Laureate Institute for Brain Research (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1001/jamapsychiatry.2024.4825
- Citations
- 8
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 14.54