Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations
Our findings underscore the pivotal role of instantaneous dose rate in reducing radiation damages. When the instantaneous dose rate is sufficiently high (> 10<sup>5</sup> Gy/s), both ultra-high or low mean dose rate irradiation (HH and LH mode) reduced mice mortality, myelosuppression, DNA damage, and cell apoptosis. Understanding these dose rate effects and biological responses are crucial for optimizing radiotherapy strategies and exploring the potential benefits of UHDR irradiation.
Authors
- Rong Xiang (ORCID: https://orcid.org/0000-0002-5521-3615)
- Rui Qiu (ORCID: https://orcid.org/0000-0002-3511-6164)
- Ankang Hu (ORCID: https://orcid.org/0000-0002-0348-7454)
- Shihua Liu (ORCID: https://orcid.org/0009-0005-1806-0620)
- Yinuo Zhu
- Wanyi Zhou
- Hao Zha (ORCID: https://orcid.org/0000-0001-5416-6557)
- Weihang Gu (ORCID: https://orcid.org/0000-0003-4513-8700)
- Xiaowu Deng (ORCID: https://orcid.org/0000-0003-2923-1251)
- Chong Zhao (ORCID: https://orcid.org/0000-0003-3271-5783)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9482-5227)
- Peng Huang (ORCID: https://orcid.org/0000-0002-2152-9152)
- Junli Li (ORCID: https://orcid.org/0000-0002-3888-5735)
- Hongyu Zhu (ORCID: https://orcid.org/0000-0003-4136-0910)
- Jiaqi Qiu (ORCID: https://orcid.org/0000-0002-9178-6998)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Shenwu Technology Group Corp (China) (CN)
- Sun Yat-sen University Cancer Center (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s10020-025-01135-3
- Citations
- 8
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 12.15
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China