Regulation of Smad2/3 Nuclear Exclusion by Follicle-Stimulating Hormone (FSH) in Chicken Follicular Granulosa Cells and Its Effect on FOXO3/4
FSH can inhibit Smad2/3 phosphorylation and retain it in the nucleus through the PI3K signaling pathway. Smad2/3 and FOXO3/4 act as downstream effectors of the PI3K signaling pathway, and Smad2/3 can promote the phosphorylation of FOXO3/4.
Authors
- Simushi Liswaniso (ORCID: https://orcid.org/0000-0003-0809-0699)
- Chunchi Yan (ORCID: https://orcid.org/0000-0002-9782-3841)
- Rifu Xu (ORCID: https://orcid.org/0000-0001-8611-9309)
- Ning Qin (ORCID: https://orcid.org/0000-0002-5387-353X)
- Xue Sun (ORCID: https://orcid.org/0000-0001-8388-2237)
- Yuhan Sun (ORCID: https://orcid.org/0009-0008-3761-9161)
- Hansheng Wu (ORCID: https://orcid.org/0009-0005-2338-4048)
Institutions
- Jilin Agricultural University (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3390/genes16030283
- Citations
- 2
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China