Evaluation of Children and Adolescents with Thalassemia Major in Terms of Osteoporosis: A Single-Centre Experience

<b>Background/Objectives</b>: This study aimed to determine the frequency of osteoporosis in children and adolescents with thalassemia major (TM) and to identify risk factors for the early development of osteoporosis. <b>Methods</b>: This retrospective study included 27 patients under 18 years of age receiving regular blood transfusions and chelation therapy for TM at our hospital. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry, and a lumbar spine Z-score <-2 was considered osteoporotic. Patients with osteoporosis were classified as Group 1 and those without osteoporosis as Group 2. <b>Results:</b> Osteoporosis was detected in 22.2% of the study population. The mean age was 13.83 ± 2.85 years in Group 1 and 7.95 ± 5.05 years in Group 2 (<i>p</i> = 0.012). Body weight and height were significantly lower in Group 1 (<i>p</i> = 0.012 and <i>p</i> = 0.004). Ferritin levels were 5306 ± 1506 ng/mL in Group 1 and 2020 ± 1205 ng/mL in Group 2, and the difference was significant (<i>p</i> = 0.001). Group 1 had significantly lower Ca and P levels (<i>p</i> < 0.001, <i>p</i> = 0.038). BMD was negatively correlated with ferritin (r = -0.791, <i>p</i> < 0.001) and positively correlated with calcium (r = 0.499, <i>p</i> = 0.008). <b>Conclusions</b>: Osteoporosis is a common condition in TM patients. Patients with risk factors should be followed more closely. These patients should be identified before BMD decreases. To prevent osteoporosis, regular BMD scans should be performed, calcium and vitamin D supplementation should be provided, and physical activity should be encouraged.