Tailored manganese ferrite nanoparticles with enhanced magnetic properties for effective hyperthermia cancer therapy

Magnetic hyperthermia, a transformative nanotechnology-based approach, has redefined cancer therapy by enabling precise and localized treatment. In this study, manganese ferrite (MnFe 2 O 4 ) nanoparticles were synthesized via a thermal decomposition method, achieving exceptional magnetic and structural properties tailored for therapeutic applications. Advanced characterization techniques, including field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM), confirmed the nanoparticles’ high crystallinity, chemical stability, and biocompatibility. Optimized synthesis conditions using 7.5 mmol of oleylamine and oleic acid surfactants produced nanoparticles with superior performance, exhibiting the lowest coercivity (15.7 Oe) and the highest saturation magnetization (33 emu/g). These features translated into remarkable magnetic hyperthermia efficiency, with a specific loss power (SLP) of 148.2 W/g in hexane media and 188.3 W/g in aqueous media, underscoring their ability to generate localized heat selectively. The thermal decomposition technique provided precise control over nanoparticle morphology and uniformity, ensuring their applicability in targeted cancer therapies. This study not only advances the understanding of MnFe 2 O 4 nanoparticle synthesis and properties but also establishes their pivotal role in next-generation therapeutic technologies, emphasizing the intersection of condensed matter physics and biomedical innovation. • MnFe2O4 nanoparticles synthesized via thermal decomposition demonstrated optimal magnetic properties with notably low coercivity (15.7 Oe) and high saturation magnetization (33 emu/g) when using 7.5 mmol surfactant concentration. • Advanced characterization through FESEM, XRD, and VSM confirmed the successful synthesis of highly crystalline and chemically stable manganese ferrite nanoparticles suitable for biomedical applications. • The optimized synthesis conditions using dual surfactants (oleylamine and oleic acid) enabled precise control over nanoparticle morphology and uniformity, essential for therapeutic effectiveness. • The synthesized nanoparticles achieved a remarkable specific loss power (SLP) of 148.2 W/g, demonstrating exceptional magnetic hyperthermia efficiency for potential cancer treatment applications.