Refractory ulcers of both legs with psoriasis vulgaris successfully treated with dehydrated human amnion/chorion membrane: A case report

Patients with psoriasis are particularly susceptible to skin damage and secondary infections due to impaired skin defenses and chronic inflammation. This case report describes an 80-year-old male with psoriasis vulgaris and a refractory venous stasis ulcer that successfully achieved epithelialization following treatment with dehydrated human amnion/chorion membrane (dHACM; EPIFIX®). Despite initial management involving infection control and wound debridement, the ulcer exhibited minimal improvement until the application of dHACM. Within 4 wk, substantial wound contraction and epithelialization were achieved, eliminating the need for skin grafting. The regenerative properties of dHACM, employed in accordance with the TIMERS framework, facilitated effective wound healing through a minimally invasive approach. This case represents the first documented use of dHACM for a venous ulcer in a patient with psoriasis vulgaris, underscoring its potential as an innovative therapeutic option for managing chronic ulcers.