Locus Coeruleus Sexual Dimorphism and Its Impact on Cognitive Impairment and Cortical Atrophy in Alzheimer’s Disease
LC structure and function may differ between sexes, influencing AD pathophysiology through distinct mechanisms. While this sexual dimorphism may have a minor role, it should be considered in clinical investigations and drug development research.
Authors
- Filippo Sean Giorgi (ORCID: https://orcid.org/0000-0002-2940-8128)
- Gloria Tognoni
- Nicola Pavese (ORCID: https://orcid.org/0000-0002-6801-6194)
- Francesca Frijia (ORCID: https://orcid.org/0000-0003-3802-326X)
- Francesco Paolo Lombardo (ORCID: https://orcid.org/0000-0002-6943-2966)
- Alessandro Galgani (ORCID: https://orcid.org/0000-0002-1894-4128)
- Marco Scotto
Institutions
- University of Pisa (IT)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Italian Institute of Technology (IT)
- Fondazione Stella Maris (IT)
- Fondazione Toscana Gabriele Monasterio (IT)
- Newcastle University (GB)
Publication Details
- Journal
- Neurodegenerative Diseases
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1159/000544882
- Citations
- 3
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Ministero della Salute