Inhibition of IL-6 trans-signaling promotes post-stroke functional recovery in a sex and dose-dependent manner
These findings demonstrate that inhibition of IL-6 trans-signaling with gp130Fc improves long-term functional outcomes in both male and female mice, albeit in a dose-dependent manner. This study provides novel insights into potential therapeutic strategies targeting IL-6 signaling pathways following stroke.
Authors
- Kate Mendoza
- Cassandra L. Hall (ORCID: https://orcid.org/0000-0001-8247-0193)
- Chunfeng Tan (ORCID: https://orcid.org/0000-0001-7083-1529)
- Anjali Chauhan (ORCID: https://orcid.org/0000-0002-9825-8100)
- Dustin T. Nguyen
Institutions
- The University of Texas Health Science Center (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s12974-025-03365-y
- Citations
- 11
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 9.26
Funders
- National Institute of Neurological Disorders and Stroke