Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24
NET-derived elastase inactivated PAR2 canonical signaling and promoted phagocytosis by downregulating CD24, which functions as a phagocytotic checkpoint in CRC liver metastasis. Thus, PAR2 inhibitors combined with CTX may serve as a novel therapeutic strategy against advanced CRC.
Authors
- Yinong Wang (ORCID: https://orcid.org/0000-0003-0954-3493)
- Fanyu Zhang (ORCID: https://orcid.org/0000-0002-9102-3704)
- Junhu Yuan
- B.-C. Wang (ORCID: https://orcid.org/0000-0001-6243-6676)
- Yu Liu (ORCID: https://orcid.org/0000-0001-8928-2558)
- Xiaoli Zhang (ORCID: https://orcid.org/0000-0002-0770-5594)
- Kun Chen (ORCID: https://orcid.org/0000-0003-3146-2577)
- Hongying Wang (ORCID: https://orcid.org/0000-0001-8443-3839)
- Jianhui Ma (ORCID: https://orcid.org/0009-0003-6677-9774)
- Yiming Ma (ORCID: https://orcid.org/0000-0001-5359-2802)
- Xinhua Zhao (ORCID: https://orcid.org/0000-0003-0772-8240)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- Beijing Institute of Neurosurgery (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010813
- Citations
- 11
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.77
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Molecular Oncology