Enhanced thrombopoiesis supplies PD-L1 to circulating immune cells via the generation of PD-L1-expressing platelets in patients with lung cancer
These findings highlight the role of tumor-associated thrombopoiesis in generating PD-L1-expressing platelets that may serve as a resource for PD-L1-positive cells in the circulation and act as a predictive biomarker for anti-PD-1/PD-L1 therapy.
Authors
- Hee‐Ok Kim
- Cheol‐Kyu Park (ORCID: https://orcid.org/0000-0001-8701-0786)
- Ju Sik Yun (ORCID: https://orcid.org/0000-0002-5167-3454)
- Woo Kyun Bae (ORCID: https://orcid.org/0000-0003-0267-1943)
- Sook Jung Yun (ORCID: https://orcid.org/0000-0003-4229-5831)
- Eu Chang Hwang (ORCID: https://orcid.org/0000-0002-2031-124X)
- In‐Jae Oh (ORCID: https://orcid.org/0000-0003-4837-1321)
- Ji Yeon Noh (ORCID: https://orcid.org/0000-0002-4158-9443)
- Kyung Na Rho
- Sung‐Woo Lee (ORCID: https://orcid.org/0000-0002-1470-3466)
- Hyun-Ju Cho (ORCID: https://orcid.org/0000-0002-2308-5997)
- Jae-Ho Cho (ORCID: https://orcid.org/0000-0002-3081-7674)
- Young Ju Kim
- Deok Hwan Yang
- Saei Jeong
Institutions
- Korea Engineering Consultants Corporation (KR)
- Chonnam National University Hwasun Hospital (KR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010193
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Research Foundation
- Chonnam National University
- Republic of Korea National Red Cross
- National Research Foundation of Korea