Beyond the loss of beta cells: a quantitative analysis of islet architecture in adults with and without type 1 diabetes
Using a novel analysis pipeline, statistical evidence supports the existence of an M-C structure in human adult islets, irrespective of type 1 diabetes status. The methods presented in the current study offer potential applications in spatial biology, islet immunopathology, transplantation and organoid research, and developmental research.
Authors
- Knut Dahl‐Jørgensen (ORCID: https://orcid.org/0000-0002-6952-9899)
- Pia Leete (ORCID: https://orcid.org/0000-0002-4013-0040)
- Noel G. Morgan (ORCID: https://orcid.org/0000-0003-1537-8113)
- Kyle C. A. Wedgwood (ORCID: https://orcid.org/0000-0002-8109-2765)
- Peter Ashwin (ORCID: https://orcid.org/0000-0001-7330-4951)
- Conor McMullan (ORCID: https://orcid.org/0000-0002-3329-1559)
- Lars Krogvold (ORCID: https://orcid.org/0000-0002-1057-7095)
- Nicolás Verschueren (ORCID: https://orcid.org/0000-0002-1086-4625)
Institutions
- Oslo University Hospital (NO)
- Engineering and Physical Sciences Research Council (GB)
- University of Oslo (NO)
- University of Exeter (GB)
- NIHR Exeter Clinical Research Facility (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1007/s00125-025-06376-9
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Diabetes UK
- Engineering and Physical Sciences Research Council