Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma
SIRT3 overexpression activated the AMPK/mTOR pathway and triggered ATG16L1-mediated autophagy, promoting ferroptosis in SCC15 cells, and we proposed that quercetin may be a promising therapeutic drug for OSCC.
Authors
- Di Xiong (ORCID: https://orcid.org/0000-0001-5502-1464)
- Jin Wang (ORCID: https://orcid.org/0000-0003-3625-7919)
- Jiahui Yang (ORCID: https://orcid.org/0000-0003-3777-8222)
- Ling Chen (ORCID: https://orcid.org/0000-0001-5544-1186)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Tongren Hospital (CN)
- Wuhan Third Hospital (CN)
Publication Details
- Journal
- Human & Experimental Toxicology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1177/09603271251323753
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06