Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium <i>Hyella patelloides</i> LEGE 07179
Recent analyses of genome data indicate that members of the cyanobacterial order Pleurocapsales show tremendous potential for natural product discovery. However, only a few compounds have been reported from this order. Here, we report the isolation of hyellamide (<b>1</b>), a glycosylated N-acyl tyrosine-derived eneamide, from the pleurocapsalean cyanobacterium <i>Hyella patelloides</i> LEGE 07179. The putative biosynthetic gene cluster for <b>1</b> was identified in the genome of the producing organism and a biosynthetic proposal is presented. This work sheds light on the chemistry of the Pleurocapsales and expands the chemical repertoire of cyanobacterial natural products to include N-acyl tyrosine-derived molecules.
Authors
- Sara Freitas (ORCID: https://orcid.org/0000-0002-3345-4100)
- Raquel Castelo‐Branco (ORCID: https://orcid.org/0000-0001-6627-0140)
- Teresa P. Martins (ORCID: https://orcid.org/0000-0002-0594-8584)
- Pedro N. Leão (ORCID: https://orcid.org/0000-0001-5064-9164)
- Vitor Manuel Vasconcelos (ORCID: https://orcid.org/0000-0003-3585-2417)
- Paula Tamagnini (ORCID: https://orcid.org/0000-0003-4396-2122)
- William H. Gerwick (ORCID: https://orcid.org/0000-0003-1403-4458)
- Adriana Rego (ORCID: https://orcid.org/0000-0001-9647-1197)
- Ângela Brito (ORCID: https://orcid.org/0000-0001-5153-5230)
Institutions
- Scripps Institution of Oceanography (US)
- Universidade do Porto (PT)
- University of California San Diego (US)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Instituto de Biologia Molecular e Celular
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c00968
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia
- H2020 Spreading Excellence and Widening Participation
- H2020 European Research Council